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ACNE

Supporting Clear Skin for all Ages and Severities

Acne
Acne
Acne
Acne
Acne
Acne

Acne vulgaris is the most common skin disease in the United States, affecting up to 50 million Americans, and approximately 85% of adolescents at some point during their teenage years. While often associated with puberty, acne does not resolve for everyone: more than 60% of people seeking treatment are adults aged 18 and older, and adult women are increasingly affected well into their 30s and 40s. The condition presents across a spectrum of severity, from non-inflammatory blackheads and whiteheads to deeper, painful inflammatory papules, pustules, nodules, and cysts, most commonly on the face, chest, and back.1,2

Acne develops as a result of several connected processes occurring in the skin: increased oil (sebum) production, often driven by hormonal changes; improper shedding of dead skin cells, which can clog pores (hair follicles); growth of bacteria (C. acnes) within clogged pores; and an inflammatory response, leading to redness, swelling, and pimples. These processes are closely linked, meaning that when one is affected, the others may also be influenced. For this reason, effective acne treatment often targets multiple causes at the same time. Additional factors such as genetics, diet, stress, and the balance of bacteria on the skin can also impact how acne develops and its severity.2,3
The consequences of acne extend well beyond the skin. Depression, anxiety, and social isolation are well-documented comorbidities, and research consistently shows that the emotional and psychological impact of acne does not necessarily correlate with its clinical severity, even mild acne can cause profound distress. Permanent scarring affects a meaningful portion of patients and compounds the psychosocial burden significantly, with studies showing that 62% of acne scar patients exhibit depressive symptoms and 84% report a diminished quality of life.2,3,4,5,6

POTENTIAL TREATMENTS

AMZEEQ® is a prescription medicine used on the skin (topical) for the treatment of pimples and red bumps (non-nodular inflammatory lesions) of moderate to severe acne in patients 9 years of age and older.

AMZEEQ should not be used for the treatment of infections. It is not known if AMZEEQ is safe and effective in children under 9 years of age. AMZEEQ is for use on skin only (topical use). AMZEEQ is not for use in your mouth, eyes or vagina.

Important Safety Information

TARGADOX® is a tetracycline-class antimicrobial indicated as adjunctive therapy for severe acne.

To reduce the development of drug-resistant bacteria as well as to maintain the effectiveness of TARGADOX and other antibacterial drugs, TARGADOX should be used only as indicated.

TARGADOX should not be used by persons who have shown hypersensitivity to any of the tetracyclines.

Important Safety Information
References:
  1. American Academy of Dermatology Association. Skin Conditions by the Numbers.
    www.aad.org/media/stats-numbers
  2. Sutaria, Amita, et al. “Acne Vulgaris.” National Library of Medicine, StatPearls Publishing.
    https://www.ncbi.nlm.nih.gov/books/NBK459173/
  3. Vasam, M., Korutla, S., & Bohara, R. A. (2023). Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochemistry and Biophysics Reports, 36, 101578.
    https://doi.org/10.1016/j.bbrep.2023.101578
  4. Layton, A. M., Bettoli, V., Delore, V., Puentes, E., & Tan, J. K. L. (2026). The Burden of Acne Vulgaris on Health-Related Quality of Life and Psychosocial Well-Being Domains: A Systematic Review. American Journal of Clinical Dermatology, 27(1), 17–47.
    https://doi.org/10.1007/s40257-025-00983-3
  5. Zhou, C., Vempati, A., Tam, C., Khong, J., Vasilev, R., Tam, K., Hazany, S., & Hazany, S. (2023). Beyond the Surface: A Deeper Look at the Psychosocial Impacts of Acne Scarring. Clinical, Cosmetic and Investigational Dermatology, 16, 731–738.
    https://doi.org/10.2147/CCID.S406235
  6. Majzoub, M., Goubeau, E., & Moris, V. (2025). Assessing the Psychosocial Impact of Acne Scars on Individuals With Pigmented Skin: A Multicenter Observational Study. Dermatology Research and Practice, 2025, 6657441.
    https://doi.org/10.1155/drp/6657441
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IMPORTANT SAFETY INFORMATION

  • Do not use AMZEEQ if you are allergic to AMZEEQ or any tetracycline medicine. Stop using AMZEEQ right away and call your doctor if you get a rash or other allergic symptom.
  • Before using AMZEEQ, tell your doctor about all of your medical conditions and the medicines you take. Do not use AMZEEQ if you are pregnant, may become pregnant or are nursing. If you become pregnant while using AMZEEQ, talk to your doctor. Tetracycline medicine when taken by mouth during pregnancy, infancy and/or childhood up to the age of 8 years may permanently discolor teeth (yellow-gray-brown) and may slow the growth of bones.
  • AMZEEQ is flammable. Avoid fire, flame, and smoking when applying and right after you apply AMZEEQ.
  • Protect your skin from the sun while using AMZEEQ. Avoid sunlight or artificial sunlight such as sunlamps or tanning beds. Stop using AMZEEQ if you get a sunburn.
  • When taken by mouth, minocycline may cause feelings of lightheadedness, dizziness or spinning. You should not drive or operate dangerous machinery if you have these symptoms.
 

AMZEEQ is a topical foam that contains minocycline, a tetracycline medicine. It is not taken by mouth. However, tetracyclines, when taken by mouth (capsules or tablets), may cause serious side effects, including: diarrhea which may be caused by an infection and can cause watery or bloody stools; loss of appetite; tiredness; yellowing of your skin or eyes (jaundice); bleeding more easily than normal; confusion; sleepiness; vision changes, including blurred vision, double vision, or permanent vision loss; unusual headaches; fever; rash; joint pain; body weakness; discoloration or darkening of your skin, scars, teeth, or gums. Call your doctor right away if these side effects occur.

The most common side effect of AMZEEQ is headache.

These are not all of the possible side effects with AMZEEQ. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

INDICATION

AMZEEQ® (minocycline) topical foam, 4% is a prescription medicine used on the skin (topical) for the treatment of pimples and red bumps (non-nodular inflammatory lesions) of moderate to severe acne in patients 9 years of age and older.

AMZEEQ should not be used for the treatment of infections. It is not known if AMZEEQ is safe and effective in children under 9 years of age. AMZEEQ is for use on skin only (topical use). AMZEEQ is not for use in your mouth, eyes or vagina.

Please see full Prescribing Information and Patient Information.

 

IMPORTANT SAFETY INFORMATION

INDICATIONS AND USAGE

TARGADOX® (doxycycline hyclate tablets) is a tetracycline-class antimicrobial indicated as adjunctive therapy for severe acne. To reduce the development of drug-resistant bacteria as well as to maintain the effectiveness of TARGADOX and other antibacterial drugs, TARGADOX should be used only as indicated. The usual dose of oral doxycycline is 200mg on the first day of treatment (administered 100mg every 12 hours), followed by a maintenance dose of 100mg daily. There are no adequate and well-controlled studies on the use of doxycycline in pregnant women.

CONTRAINDICATIONS

This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.

IMPORTANT SAFETY INFORMATION

TARGADOX tablets are contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.

The use of tetracycline class drugs during tooth development (last half of pregnancy, infancy, and childhood to 8 years) may cause permanent discoloration of the teeth and should not be used in this group (except for anthrax).

Clostridium difficile-associated diarrhea (CDAD) has been reported with nearly all antibacterial agents, including doxycycline, and may range from mild diarrhea to fatal colitis.

Photosensitivity can occur with tetracycline-class drugs.

TARGADOX patients should minimize or avoid excessive exposure to natural or artificial sunlight and consider using sunscreen or sunblock.

Advise patients to discontinue therapy at the first evidence of skin erythema.

Intracranial Hypertension (IH) has been associated with the use of tetracyclines.

Concurrent use of tetracycline may render oral contraceptives less effective.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate, and iron-containing preparations.

Esophagitis has been associated with the use of tetracyclines so patients should be advised to drink fluids liberally along with doxycycline.

Adverse reactions observed in patients receiving tetracyclines include anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia, toxic epidermal necrolysis, Stevens-Johnson syndrome, increased blood urea nitrogen (BUN) and hypersensitivity reactions.

 

You are encouraged to report negative side effects of prescription drugs to Journey Medical Corp. at 1-855-531-1859 or the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Click here for Full Prescribing Information.